Researchers at Columbia University Medical Center (CUMC) found Ketamine – a soothing drug, which was considerably more useful than a frequently used sedative to tackle suicidal thoughts in depressed patients. They also revealed that ketamine’s anti-suicidal effects occurred within hours after its administration.
Michael Grunebaum, a research psychiatrist at CUMC, said that there is an essential window in which depressed patients.
He added that presently accessible antidepressants can be effective in reducing suicidal thoughts in patients with depression, but they can take weeks to have an outcome. Suicidal, depressed patients require treatments that are quickly efficient in reducing suicidal thoughts when they are at a maximum risk. At present, there is no such cure for quick help of suicidal thoughts in depressed patients.
Most antidepressant trials have excluded patients with suicidal thoughts and behavior, restraining data on the result of antidepressants in this population.
Though, preceding studies have shown that low doses of Ketamine, an anesthetic drug, causes a fast decrease in depression symptoms and may be accompanied by a decrease in suicidal thoughts.
They carried out an experiment in which, 80 depressed adults with clinically important suicidal thoughts that registered in this study were by option owed to get a mixture of low-dose Ketamine or Midazolam, a downer.
Within 24 hours, the Ketamine group had a clinically important decline in suicidal thoughts that was greater than with the Midazolam group. Those in the Ketamine group also had greater expansion in overall mood, depression, and fatigue compared with the Midazolam group. Ketamine’s effect on depression accounted for around one-third of its effect on suicidal thoughts, suggesting the treatment has an explicit anti-suicidal effect.
Researchers find some side effects, mainly dissociation (feeling spacey) and an increase in blood pressure during the infusion, were mild to moderate and typically resolved within minutes to hours after receiving Ketamine.
Dr. Grunebaum said that this study shows that Ketamine is speedily acting cure for reducing suicidal thoughts in patients with depression.